The Honda Odyssey cuts a curvy profile, and its front end looks similar to the Accord sedan. Large headlights flank its big grille. The hood is sculpted with curves that lead naturally back to the windshield and emphasize the big fender flares. Honda has not hidden the sliding door channels at the base of the window but left them partially obscured by a crease that runs the length of the vehicle.

All models come with two sliding doors, manually operated on the LX and electrically operated on all other models. The power windows in each of the side doors can be opened in the same fashion as in a car. The tailgate is electrically operated in the top-of-the-line Touring. The power doors seemed a bit reluctant to operate at times, and less responsive to key fob commands than the sliding doors on the Toyota Sienna.

The Odyssey boasts Honda's Advanced Compatibility Engineering (ACE) body structure. The vehicle's crush zones have been engineered to provide good protection for occupants while minimizing damage in a collision with smaller vehicles and pedestrians. Its body structure is rigid, which contributes to crisp handling and a smooth ride. A low drag coefficient helps improve fuel economy and high-speed stability.