Options include satellite navigation with Bluetooth, XM satellite radio with real-time traffic display, Mark Levinson 19-speaker, 450-watt sound system and 30-gigabyte hard drive, a pre-collision system, dynamic radar cruise control, advanced parking guidance system, Lexus Link, power trunk opener/closer, a Comfort Package, and a Comfort Plus Package. Four different rear-seat packages are available for the 460L.

Safety is a primary consideration for luxury car buyers, and the LS 460 fairly drips with safety equipment, from eight standard air bags to ABS (anti-lock brakes), electronic brake assist, ESP (electronic stability program), adaptive front lighting that turns corners, and tire pressure monitoring. With the optional two-seat rear compartment, there is an additional air bag in the mix, and there are more safety options, including a pre-collision system that moves seats to a neutral position, closes the windows and sunroof, and tightens belts when the computers detect an impending collision.